强迫症患者生活质量及相关因素的研究

Quality of life and its related factors in patients with obsessive-compulsive disorder

目的:探讨强迫症(OCD)患者的生活质量及其相关因素。方法:采用耶鲁布朗OCD量表评估63例OCD患者(OCD组)病情;并应用生活质量量表(SF-36)对患者、患者一级亲属(家属组,63人)及正常对照者(对照组,63人)进行评估。结果:除生理机能项外,OCD组SF-36各项评分明显低于对照组及家属组(P均<0.01)。OCD患者强迫思维评分与生理职能分(r=-0.419)、精力分(r=-0.42)、社会功能分(r=-0.385)、情感职能分(r=-0.496)、精神健康分(r=-0.439)呈显著负相关(P均分<0.01);强迫行为评分与生理职能(r=-0.381)、情感职能分(r=-0.511)、精神健康(分r=-0.429)呈显著负相关(P均<0.01)。强迫总分与生活质量的生理职能分(r=-0.402)、精力分(r=-0.353)、社会功能分(r=-0.366)、情感职能分(r=-0.51)、精神健康分(r=-0.457)呈显著负相关(P均<0.01)。多元回归分析显示,生理职能分与强迫思维分相关(F=10.974,P=0.001,R2=0.175);躯体疼痛分与强迫行为分相关(F=6.658,P=0.012,R2=0.098);精力分与强迫行为分、强迫思维分相关(F=11.459,P=0.000,R2=0.276)、社会功能与强迫思维分相关(F=10.518,P=0.002,R2=0.147);情感职能与强迫行为分、自知力相关(F=15.339,P=0.000,R2=0.316);精神健康与强迫思维、性别相关(F=11.731,P=0.000,R2=0.281)。结论:OCD患者生活质量差,其年龄、性别、强迫思维及行为、以及自知力在不同方面影响其生活质量。

Objective：To explore the quality of life and it＇s related factors in patients with obsessive-com- pulsive disorder （OCD）. Method：Sixty three OCD patients were assessed by Yale-Brown obsessive-compul- sive scale （YBOCS）. The quality of life was evaluated by quality of life scale （ SF-36 ） in the 63 OCD patients （OCD group）,their first-degree relatives （family group, 63 poisons ） and normal controls （control group, 63 people）. The influencing factors of quality of life in the patients were analyzed. Results： In OCD group, exept physiological function item ,the scores of all the items of SF-36 were significantly lower than control group and family group （all P 〈 0.01 ）. In OCD patients, the score of obsessive thinking was negatively correlated to scores of physiological function（ r = - 0. 419 ）, energy （ r = - 0.42 ）, social function （ r = - 0. 385 ）, emotional （ r = - 0.496） and mental health （ r = - 0. 439 ） （ all P 〈 0.01 ）. The score of compulsive behavior was negatively correlated to scores of physiological function （ r = - 0.381 ）, emotional （ r = - 0.511 ） and mental health （ r = - 0. 429 ） （ all P 〈 0.01 ）. The total score of YBOCS was negatively correlated to physiological function （ r = - 0. 402 ） , energy （ r = - 0.353 ） , social function （ r = - 0. 366 ） , emotional （ r -- - 0.51 ） and mental health functions （ r = - 0.457 ） of SF-36 （ all P 〈 0.01 ）. Multiple regression analysis showed that, physiological func- tion score was correlated to obsessive thinking score （F = 10. 974, P = 0. 001, R2 = 0. 175 ） ;the bodily pain score was correlated to eompplsive behavior score（ F = 6. 658, R2 = 0.098 ） ; energy score was correlated to scores of obsessive thinking and compulsive behavior（ F = 11. 459, P = 0. 000, R2 = 0. 276） ; social function score was cor- related to obsessive thinking score（ F = 10. 518 ,P = 0. 002, R2 = 0. 147 ）;emotional score was correlated to scores of compulsive behavior and self-knowledge （ F = 15. 339, P = 0. 000, R2 = 0. 316 ） ; mental health score was correlated to obsessive thinking score and gender （ F = 11. 731, P = 0. 000, R2 = 0. 281 ）. Conclusion： The quality of life in OCD patients is low and affected at different aspects by age,gender,obsessive thinking and behavior,and self-knowledge.