摘要
目的:探讨齐拉西酮与氯丙嗪对精神分裂症患者认知功能的影响。方法:80例精神分裂症患者随机分为研究组和对照组,并分别给予齐拉西酮或氯丙嗪治疗8周。分别于治疗前和治疗后应用威斯康星卡片分类测验、韦氏记忆测验和河内塔测验评定两组患者的认知功能。结果:治疗8周后,研究组威斯康星卡片分类测验、韦氏记忆测验及河内塔测验各项成绩明显优于治疗前和对照组(P均<0.05)。结论:与氯丙嗪比较,齐拉西酮能明显改善精神分裂症患者的认知功能。
Objective ：To explore the effect of ziprasidone and chlorpromazine on cognitive function in pa- tients with schizophrenia. Method ： Eighty schizophrenia patients were randomly divided into the research group and control group, each of which accepted the treatment with ziprasidone or chlorpromazine respectively for 8 weeks. Before and after treatment, the cognitive function were evaluated by Wisconsin card sorting test （WCST）, Wechsler memory scale （WMS） and tower of Hanoi （TOH） in the two groups. Results：After 8 weeks of treatment,all the results of WSCT,WMS and TOH in research group were significantly better than be- fore treatment and control group （ all P 〈 0.05 ）. Conclusion： Compared with chlorpromazine, ziprasidone can remarkably improve the cognitive function in patients with schizophrenia.
出处
《临床精神医学杂志》
2013年第5期327-329,共3页
Journal of Clinical Psychiatry
关键词
齐拉西酮
氯丙嗪
精神分裂症
认知功能
ziprasidone
chlorpromazine
schizophrenia
cognitive function
