度洛西汀与帕罗西汀治疗惊恐障碍患者对照研究

Comparison of duloxetine and paroxetine in treatment of pationts panic disorder

目的:比较度洛西汀和帕罗西汀治疗惊恐障碍的疗效及安全性。方法:将80例符合惊恐障碍诊断标准患者随机分为两组,分别予以度洛西汀(40例)和帕罗西汀(40例)进行治疗,疗程12周。采用惊恐障碍相关症状量表(PASS)、汉密尔顿焦虑量表(HAMA)、健康状况问卷(SF-36)、临床疗效总评量表-病情严重程度(CGI-SI)评定疗效,以治疗时出现的症状量表(TESS)评定不良反应。结果:经过12周治疗,度洛西汀组和帕罗西汀组总有效率分别为92.11%和94.74%,,两组疗效差异无统计学意义(P>0.05),两组不良反应发生率无统计学意义(P>0.05)。结论:度洛西汀和帕罗西汀对惊恐障碍疗效相当,不良反应较小。

Objective： To investigate the efficacy and safety of duloxetine and paroxetine in treatment Of panic disorder. Method：Eighty patients with panic disorder were randomly allocated to two groups, treated with duloxetine and paroxetine respectively for 12 weeks. The panic-associated symptom （PASS）, Hamilton anx- iety scale （ HAMA ）, the MOS item short from health survey （SF-36） and clinical global impression scale-se- verity of illness （CGI-SI） were used to assess the therapeutic effectiveness and treatment emergent symptom scale （TESS） was used to evaluated side effect. Results：The total efficient rate of duloxetine group and par- oxetine group are 92.11% and 94.74% respectively. There was no significant difference between two groups in improvement rate and side effect （ P 〉 0.05 ）. Conclusion： Duloxetine is as effective as paroxetine for the treatment of panic disorder with fewer side effects.