医院感染鲍曼不动杆菌的临床分布及耐药性研究

Clinical distribution and drug resistance of baumanii infection in hospital

目的探讨鲍曼不动杆菌的临床分布及耐药情况。方法对2010年5月～2013年5月期间住院患者送检的标本中分离出的498株鲍曼不动杆菌进行研究，分析各类标本与不同病区中鲍曼不动杆菌的分布及对各类抗生素的耐药情况。结果呼吸道痰标本中鲍曼不动杆菌分离最高，构成比为84．14％，并且与中段尿标本中鲍曼不动杆菌检出率比较差异有统计学意义（P〈0．05）。ICU为鲍曼不动杆菌主要分布的科室，构成比为36．75％，其次为呼吸内科21．89％、感染科15．26％。鲍曼不动杆菌对头孢唑啉的耐药率为99．20％、头孢呋辛97．79％、头孢替坦97．19％、头孢呋辛酯98．19％、复方新诺明91．77％、呋喃妥因98．39％。结论临床在选择抗菌药物进行治疗时应以药物的药敏结果为参考依据，选择具有较低耐药率的药物应用于临床。

Objective To investigate the clinical distribution and drug resistance of baumanii in our hospital. Methods A total of 498 strains of Bauman Acinetobacter researched were isolated from hospitalized patients in the specimen from 2010 May to 2013 May, various samples and the disease area of Bauman Acinetobacter distribution and drug re- sistance to different antibiotics were analyzed. Results Sputum of respiratory tract of baumanii isolated highest, the ratio was 84.14%, and compared with the middle segment urine samples, the detected rates with the significant difference （P 〈 0.05）. ICU was baumanii main distribution department, and the ratio was 36.75%, followed by respiratory depart- ment of internal medicine, the ratio was 21.89%, department of infection, the ratio was 15.26%. Baumanii resistance to cefazolin was 99.20%, cefuroxime was 97.79%, cefotetan was 97.19%, cefuroxime was 98.19%, cotrimoxazole was 91.77%, uitrofurantoin was 98.39%. Conclusion Clinical drug treatment should be based on the drug sensitivity re- sults as the reference drug with low resistance rate of drug application in clinical.