薄壁滤过泡对青光眼患者泪液中抗坏血酸浓度的影响

The change of tear composition with thin-wall bleb in glaucoma patients

目的探讨青光眼患者薄壁滤过泡的存在对患眼泪液成分的影响。设计横断面研究。研究对象选择距抗青光眼滤过术后至少6个月的薄壁滤过泡患者10例、厚壁滤过泡患者11例和无滤过泡者15例。方法利用紫外分光光度计测量以上三组患者泪液中抗坏血酸的含量。主要指标泪液中抗坏血酸浓度。结果薄壁滤过泡组、厚壁滤过泡组和无滤过泡组泪液中抗坏血酸含量分别为(713.53±132.32)μg/ml,(502.52±93.90)μg/ml和(470.95±86.85)μg/ml,三组间存在统计学差异(F=18.117,P=0.000),薄壁滤过泡组抗坏血酸浓度显著高于无滤过泡组和厚壁滤过泡组(P=0.000,P=0.000),而厚壁滤过泡组与无滤过泡组间无显著差异(P=0.446)。结论青光眼患病术后薄壁滤过泡中的房水可经由菲薄的结膜组织渗出至眼表,改变患眼的泪液组成。

Objective To investigate the influence of thin-wall bleb on tear composition of glaucoma patients. Design Cross sec- tional observation. Participants 10 patients with thin-wall blebs, I 1 patients with thick-wall blebs, which were enrolled more than 6 months after filtering surgery, and 15 patients without filtering blebs were involved. Methods The concentration of ascorbic acid in tear was determined by ultraviolet spectrophotometer. Main Outcome Measures The concentration of ascorbic acid in tear. Results The concentration of aseorbic acid was （713.53±132.32）μg/ml in thin-wall bleb group, （502.52±93.90）μg/ml in thick-wall bleb group, and （470.95±86.85）μg/ml in without filtering blebs group, respectively. There was significant difference among the three groups （F=18.117,P=0.000）. The concentration of ascorbic acid in thin-wall bleb group was significantly higher than that in thick-wall bleb group and without filtering blebs group （P=0.000, P=0.000）. There was not significant difference between thick-wall bleb group and without filtering blebs group （P=0.446）. Conclusion Aqueous humor can exude from the wall of thin-wall blebs to the eye surface under the pressure imposed by eyelid and as a result the composition of tear is changed.