Vlendelian randomization: loosening the Gordian knot of testosterone and male ageing
Vlendelian randomization: loosening the Gordian knot of testosterone and male ageing
摘要
It is unknown whether the reduced blood testosterone among unselected older men ("andropause") compared to healthy younger men is due to ageing per se or as a non-specific adaptive reaction to chronic diseases accumulating during ageing.
It is unknown whether the reduced blood testosterone among unselected older men ("andropause") compared to healthy younger men is due to ageing per se or as a non-specific adaptive reaction to chronic diseases accumulating during ageing.
参考文献25
-
1Corona G, Rastrelli G, Monami M, Guay A, Buvat J et al. Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study. Eur J Endocrino12011; 165; 687-701.
-
2Ruige JB, Mahmoud AM, de Bacquer D, Kaufman JM. Endogenous testosterone and cardiovascular disease in healthy men= a meta-analysis. Heart 2011; 97: 870-5.
-
3Araujo AB, Dixon JM, Suarez EA, Murad MH, Guey LT et al. Clinical review: endogenous testosterone and mortality in men: a systematic review and meta- analysis. J Clin Endocrinol Metab 2011; 96: 3007- 19.
-
4Fernandez-Balsells MM, Murad MH, Lane M, Lampropulos JE, Albuquerque F et al. Clinical review 1: adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab 2010, 95: 2560-75.
-
5Liverman CT, Blazer DG. Testosterone and Aging: Clinical Research Directions. In: Board on Health Sciences Policy. Washington, DC: Institute of Medicine; The National Academies Press; 2004. p217.
-
6Haring R, Teumer A, Volker U, Dorr M, Nauck Metal. Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality. Andrology2013; 1: 17-23.
-
7Smith GD, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003; 32: 1-22.
-
8Gray R, Wheatley K. How to avoid bias when comparing bone marrow transplantation with chemotherapy. Bone Marrow Transplant 1991: 7 (Suppl 3): 9-12.
-
9Smith GD, Timpson N, Ebrahim S. Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. Ann Med 2008; 40: 524-41.
-
10Petra P, Stanczyk FZ, Namkung PC, Fritz MA, Novy ML. Direct effect of sex-steroid binding protein (SBP) of plasma on the metabolic clearance rate of testosterone in the rhesus macaque. J Steroid Biochem Mol Bio11985; 22: 739-46.
-
1做好事的猴子[J].天天爱学习(二年级),2013(16):34-34.
-
2为什么蚂蚁对森林很重要[J].文学少年(小学低年级),2014(5):30-31.
-
3赵德荣.硒对人体健康的影响[J].中国果菜,2005,25(5). 被引量:2
-
4GE Weiwen 1 and HE Fuchu 2 1. Institute of Hygiene and Environment Medicine, Tianjin 300050, China,2. Institute of Radiation Medicine, Beijing 100850, China.Randomization of protein encoding gene during species evolution[J].Chinese Science Bulletin,1998,43(4):299-303.
-
5为什么鲨鱼容易掉牙?[J].读书与作文.低年级版,2012(12):19-19.
-
6易聪,周兰姜,周兴涛.染色质重塑复合物SAGA及其同源物的功能[J].中国生物化学与分子生物学报,2009,25(5):407-413.
-
7小渔007.回不去的过去,忘不掉的你[J].人生与伴侣(智慧),2015,0(12):18-19.
-
8Tong Zhang,Yanfang Li,Yanni Zhou,Lingyun Zhang.Cloning and expression analysis of a homologous expansin gene EXP2 in Picea wilsonii[J].Journal of Forestry Research,2016,27(2):247-255. 被引量:1
-
9松鼠拔牙[J].方圆,2016,0(13):6-6.
-
10项学敏,王晓坤,周集体,王刃,曲宝成.活性艳红X-3B及NaCl对田菁过氧化物酶活性和总酚质量分数的影响[J].兰州大学学报(自然科学版),2009,45(1):50-55.