老年非小细胞肺癌手术前后应用普米克令舒及沐舒坦雾化吸入的临床观察

Clinical observation before and after surgery using Pulmicort and Mucosolvan inhalation in elderly patients with non-small cell lung cancer

目的:观察老年非小细胞肺癌手术前后应用普米克令舒、沐舒坦雾化吸入对临床指标的影响,进一步探讨大剂量普米克令舒雾化吸入的临床疗效。方法:将90例接受开胸手术的老年非小细胞肺癌患者随机分为3组,在常规治疗基础上,于术前3 d和术后3 d观察1组予生理盐水10 ml+沐舒坦30 mg+普米克令舒1 mg、观察2组予生理盐水10 ml+沐舒坦30 mg+普米克令舒2 mg、对照组予生理盐水10 ml+沐舒坦30 mg雾化吸入,每天3次。比较3组之间PaCO2、PaO2、SaO2、、痰量、痰液pH值、术后住院天数、平均术后带管天数、术后体温、白细胞计数、中性粒细胞绝对值和中性粒细胞百分比、术后并发症等指标。结果:3组之间上述指标中除SaO2差异无统计学意义外,其余指标差异均有统计学意义(P<0.01)。与对照组比较,观察组临床指标明显改善,其中观察2组临床指标改善更显著。结论:老年非小细胞肺癌手术前后应用大剂量普米克令舒联合沐舒坦雾化吸入对减轻肺部炎症具有较好的效果。

Objective： To observe the affect on clinical indicators of Pulmicort combined with Mucosolvan atomizing inhalation before and after surgery in elderly patients with non-small cell lung cancer and to further explore the clinical efficacy of large dose Pulmicort aerosol inhalation .Methods：Ninety elderly patients with non-small cell lung cancer who underwent thoracotomy surgery were randomly divided into three groups and on the basis of routine treatment,the observation group 1 was given saline 10 ml＋Mucosolvan 30 mg ＋Pulmicort 1 mg, the observation group 2 was given saline 10 ml ＋Mucosolvan 30 mg＋Pulmicort 2 mg, the control group was given saline 10 ml＋Mucosolvan 30 mg inhalation three times a day , at three days before and after surgery , PaCO2 ,PaO2 ,SaO2 , sputum volume , sputum pH value , postoperative hospital stay days , the average postoperative days with pipe , postoperative body temperature , white blood cell values , absolute neutrophil count and neutrophil percentage , postoperative complications were compared among the three groups .Results：In addition to SaO 2 ,the rest indicators among the three groups had significantly differences （ P〈0 .01 ） .Compared with the control group , clinical indica-tors of the observation group had improved significantly and the observation groups 2 improved more significantly . Conclusion：Application of large dose of Pulmicort combined with Mucosolvan aerosol inhalation in elderly patients with non small cell lung cancer before and after operation has better effect of reducing inflammation of the lungs .