维生素E对非酒精性脂肪性肝病的疗效及机制的研究进展

Efficacy and mechanism of action of vitamin E in treatment of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的发病与氧化应激密切相关.维生素E(vitamine E,VE)是一种有效的抗氧化剂,能够通过改善氧化平衡缓解NAFLD症状,新近研究表明其发挥作用的机制并不局限于此,还包括对糖、脂质等代谢紊乱的调节.然而迄今在NAFLD治疗中,VE的应用疗效仍然存在争议,临床适用病情、药物剂量、疗程等尚待探讨.本文就VE治疗NAFLD的临床应用及机制的近期研究进展做一综述.

Non-alcoholic fatty liver disease （NAFLD） is closely related to oxidative stress. Vitamin E （VE） is an effective antioxidant, which can relieve NAFLD symptoms by improving the balance between oxidation and anti-oxidation. However, recent research indicates that the mechanism of action of VE is not only limited to anti-oxidation, but also involves adjusting glucose and lipid metabolism disorders. Currently, the efficacy of VE in the treatment of NAFLD remains contro- versial, and its indications, dosage and treatment duration remain to be optimized. In this paper we review recent progress of clinical application of VE in the treatment of NAFLD and discuss the underlying mechanism.