外科治疗原发性甲状腺机能亢进并突眼征52例临床分析

Clinical analysis of 52 cases of primary hyperthyroidism combined with exophthalmos by surgical treatment

目的分析外科治疗对原发性甲状腺功能亢进并突眼征患者突眼度的影响。方法对52例原发性甲状腺功能亢进并突眼征患者行双侧甲状腺次全切除术治疗,在手术治疗前及治疗后1 d、1个月、3个月、6个月检测患者甲功及突眼度。结果 52例患者手术后甲亢病情治愈,术后1、3、6个月突眼与术前1 d对比突眼度差异有统计学意义(P<0.05),术后患者突眼度逐渐减少,眼征好转。结论原发性甲状腺机能亢进并突眼征患者可行手术治疗,原发性甲状腺功能亢进并轻中度突眼患者外科治疗后突眼度可缩小,眼征改善。

Objective To analyze the impact of surgical treatment on patients with primary hypothyroidism combined with exophthalmos. Methods Fitby-two patients of primary hypothyroidism combined with exophthalmos were treated with bilateral subtotal thyroidectomy surgery. The thyroid function and exophthalmos degree were detect- ed 1 day before operation and 1, 3, 6 months after operation. Results Primary hypothyroidism was cured in the 52 patients. There was statistically significant differences in exophthalmos degree 1 day before operation and 1, 3, 6 months after operation （P〈0.05）. The exophthalmos degree gradually reduced, and eye symptoms were improved. Conclusion Surgical treatment is feasible for patients of primary hyperthyroidism combined with exophthalmos. The exophthalmos degree of primary hyperthyroidism and mild-to-moderate exophthalmos can be reduced after surgi- cal treatment, and the eye symptoms can be improved.