儿童哮喘不同时期与肺炎衣原体感染的关系

Correlation between chlamydia pneumoniae infections and each stage of childhood asthma

目的了解衣原体感染和儿童哮喘发作不同时期之间的关系,为临床诊断和治疗提供依据。方法将研究对象分为病例组(96例)和对照组(30例),其中病例组包括急性发作组(32例)、慢性持续组(35例)和临床缓解组(29例)三组,用ELISA法检测各组的CP-IgM、CP-IgG和CP-IgM,并分析肺炎衣原体(CP)感染和儿童哮喘不同时期的相关性。结果急性发作组CP-IgG、CP-IgM、CP-IgA阳性率分别为31.3%、28.1%和21.9%,均高于正常对照组,其中CP-IgG和CP-IgA阳性率显著高于正常对照组,差异具有统计学意义;慢性持续组CP-IgG、CP-IgM、CP-IgA阳性率分别为31.4%、22.9%和25.7%,均高于正常对照组,其中CP-IgG和CP-IgA阳性率显著高于正常对照组,差异具有统计学意义;临床缓解组CP-IgG、CP-IgM、CP-IgA阳性率分别为10.3%、6.9%和6.9%,与正常对照组比较差异无统计学意义。结论儿童支气管哮喘急性发作期和慢性持续期与肺炎衣原体感染相关,应对儿童哮喘的CP感染加以重视。

Objective To learn the correlation between chlamydia pneumoniae infections and each period of childhood asthma, and to provide information for clinical diagnosis and treatment. Methods The study subjects were divided into the acute onset period group, chronic persistent period group and clinical re- mission period group, and the control group. The chlamydia pneumoniae （CP） antibodies of IgG （CP-IgG）, IgA（CP-IgG） and IgM（CP-IgM） were detected by ELISA, and the relationship between CP infections and each period of childhood asthma was analyzed. Results The positive rates of CP-IgG, CP-IgM and CP-IgA were 31.3%, 28.1% and 21.9% in acute onset period group, 31.4%, 22.9% and 25.7% in chronic persistent period, respec- tively. The three rates in the above two groups were all higher than those in the control group, and the differences of CP-IgG and CP-IgA between the two groups were statistically significant. The positive rates of CP-IgG, CP-IgM and CP-IgA in clinical remission period group were 10.3%, 6.9%, 6.9%, showing no statistically significant differences with the control group. Conclusion There is a correlation between chlamydia pneumoniae infection and childhood asthma. We should pay attention to chlamydia pneumoniae infection in childhood asthma.