妊娠期高血压疾病患者血清Apelin水平变化及临床意义

Clinical significance of serum Apelin changes in patients with hypertensive disorder in pregnancy

目的探讨妊娠期高血压疾病患者血清Apelin水平变化及临床意义。方法妊娠期高血压疾病孕妇51例,其中单纯妊娠期高血压(GH)19例,轻度子痫前期(MP)15例,重度子痫前期(SP)17例,同期正常剖宫产孕妇16例纳入对照组,比较各组孕妇血清Apelin及血脂情况。结果 GH、MP及SP组患者血清Apelin水平均明显低于对照组,差异均有统计学意义(P<0.05),且SP组明显低于MP组,MP组明显低于GH组,差异均有统计学意义(P<0.05);相关性分析显示,妊娠期高血压疾病患者血清Apelin与TG、TC、LDL-C呈负相关,与HDL-C呈正相关(P均<0.05)。结论 Apdin可能参与妊娠期高血压疾病的发病过程。

Objective To investigate the clinical significance of serum Apelin changes in patients with hypertensive disorder in pregnancy. Methods A total of 51 pregnant women with hypertensive disorders in pregnancy, including 19 cases of simple gestational hypertension （GH）, 15 cases of mild preeclampsia （MP）, and 17 cases of severe preeelampsia （SP）. Six- teen pregnant women undergoing normal cesarean were selected as the control group. The levels of sennn Apelin and lipid profiles were compared. Results The serum Apelin in GH, MP and SP patients were significantly lower than the control group, and the differences statistically significant （P〈0.05）. The serum Apelin in the SP group was significantly lower than the MP group, and that in MP group was significantly lower than the GH group, the differences were statistically significant （P〈 0.05）. Correlation analysis showed that in patients with hypertensive disorders in pregnancy, the serum Apelin was negatively correlated with TG, TC, LDL-C and positively correlated with HDL-C （P〈0.05）. Conclusion Apelin may be involved in the pathogenesis of hypertensive disorders in pregnancy.