胰岛素抵抗ApoE基因多态性与轻度认知障碍的相关性分析

Analysis of the Correlation among Insulin Resistance ApoE Gene Polymorphism and Mild Cognitive Impairment

目的:探讨胰岛素抵抗、ApoE基因多态性的表达与轻度认知障碍(MCI)的相关性。方法:收集60例2型糖尿病胰岛素抵抗的患者,其中分为非MCI组24例,MCI组36例,和38例正常对照组进行载脂蛋白E(appolipoprotein,APOE)基因分型,计算基因频率,并对胰岛素抵抗、轻度认知障碍与ApoE基因多态性进行性关联分析。结果:MCI组ApoEε4等位基因频率显著高于对照组(P<0.01),非MCI组ApoEε4等位基因频率与对照组比较无统计学意义。胰岛素抵抗指数与APOE基因ε4呈正相关(P<0.05)。结论:胰岛素抵抗与MCI和ApoEε4存在相关性。胰岛素抵抗、ApoEε4和认知功能的测定对预测MCI的发生及转化为痴呆(AD)具有临床应用价值。

Objective： To investigate the relationship among insulin resistance, ApoE gene polymorphism and mild cognitive impairment. Method： 60 cases type 2 diabetes with insulin resistance, which was divided into 24 cases of non-MCI group and 36 cases of MCI group, and 30 healthy objects were tested for the frequency of the ApoE alleles and polymorphism, and analyzed the correlation among them. Result： The results showed that the frequency of the allele of ApoE^4 of MCI group was significantly higher than those in healthy objects group（P〈0.01 ）. Insulin resistance index and ApoE genee4 were positively correlated（P〈0. 05 ）. Conclusion： There＇s correlation between insulin resistance, ApoE gene polymorphism and mild cognitive impairment.