儿童过敏性紫癜临床特点及肾损害相关因素分析

Clinical Features of Children Allergic Purpura and Factors of Renal Damage

目的:分析儿童过敏性紫癜临床特点及肾损害相关因素。方法:选择过敏性紫癜患儿122例,将伴有肾脏功能损害者选入观察组(49例),将不伴有肾脏功能损害者选入对照组(73例),分析所有患儿临床资料,对过敏性紫癜患儿诱因及首发症状情况、临床表现及过敏性紫癜患儿肾脏功能损害的危险因素进行探讨。结果:感染为患儿最常见诱因,比例为52.46%,紫癜为患儿最常见的首发症状,比例为64.75%。临床表现包括过敏性紫癜皮疹、关节症状、消化道症状及肾脏功能损害。卡方检验显示,观察组患儿年龄≥8y、皮疹反复≥4w及血FIB升高的比例均显著高于对照组患儿,差异具有统计学意义(P<0.05)。Logistic多因素分析显示皮疹反复发生≥4w及血FIB水平升高是过敏性紫癜患儿肾脏功能损害的重要危险因素。结论:典型的皮疹、关节症状、消化道症状是过敏性紫癜患儿常见的临床表现,其常见的诱因为感染,皮疹反复发生≥4w及血FIB水平升高是过敏性紫癜患儿肾脏功能损害的重要危险因素。

Objective： To analyze the clinical features of children with Henoch purpura and renal damage related factors. Method： 22 cases of allergic purpura in children, the analysis of all children with clinical data to explore the risk factors of incentives and the first symptom in children with allergic purpura, clinical manifestations and anaphylactoid purpura in children with kidney dysfunction. Result： Infection for children with the most common causes of a ratio of 52.46%, purpura for children with the most common first symptom ratio of 64.75%. Clinical manifestations including allergic purpura rash, joint symptoms, gastrointestinal symptoms, and renal dysfunction. The chi-square test, the observation group children age more than 8 years, rash, repeatedly more than 4 weeks and elevated blood FIB ratio were significantly higher in children and the difference was statistically significant （ P 〈0.05 }. More than 4. Logistic regression analysis showed that the rash recurring more than 4 weeks and blood FIB levels anaphylactoid purpura in children with kidney dysfunction are important risk factors. Conclusion： Typical rash, joint symptoms, gastrointestinal symptoms are common clinical manifestations in children with allergic purpura, its common predisposing factors for infection, rash recurrent more than 4 weeks blood FIB level rise anaphylactoid purpura in children with kidney dysfunction important risk factors.