健肝颗粒联合经导管动脉栓塞术治疗原发性肝癌临床疗效研究

Efficacy of Jiangan granules combined with transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma

目的:观察健肝颗粒联合经导管动脉栓塞术(transcatheter arterial chemoembolization,TACE)治疗HBV DNA阳性原发性肝癌(HCC)的效果及其预后。方法:HBV DNA>103IU/ml的HCC患者126例,均予核苷类似物药抗病毒治疗,并随机分为TACE联合健肝颗粒的治疗组(62例)和TACE治疗的对照组(64例),观察两组患者肝功能Child-Pugh评分、HBV DNA定量、实体瘤体积变化和两年生存率。结果:治疗两年后,治疗组患者肝功能ChildPugh评分较对照组降低,且治疗组患者两年生存率比对照组高,其差异均有统计学意义(P<0.05);实体瘤缩小和HBV DNA定量变化两组比较差异无统计学意义(P>0.05)。结论:健肝颗粒联合TACE治疗可改善HCC患者的肝功能,提高其生存率和生活质量。

Objective： To investigate the efficacy of the addition of the Jian-gan granules to transcatheter arterial chemoem- bolization （TACE） in patients with hepatitis B virus HBV DNA-positive hepatocellular carcinoma （HCC） who received antiviral therapy with nucleoside analogues. Methods： One hundred and twenty-six HCC patients with HBV DNA 〉 10^3IU/ml were included. All patients received antiviral therapy with nucleoside analogues. Then they were randomly assigned to receive TACE alone （n = 64 ） or in combination with the Jian-gan granules （n = 62） . Two-year survival and changes in Child-Pugh scores, HBV DNA levels and solid tumor volume were assessed. Results： At 1 and 2 years, patients receiving the additional Jian-gan granules had significantly lower Child-Pugh scores and higher 2-year survival compared with controls （P 〈 0. 05 ） . There were no statistically significant differences in changes in solid tumor volume or HBV DNA levels between the two groups （ P 〉 0. 05 ） . Conclusion ： The Jian-gan granules combined with TACE may improve liver function, survival and quality of life in patients with HCC.