抗体技术研究进展(2):小分子抗体及功能复合化抗体

Recent advances in antibody technique 2. Antibodies of small-molecule and composite function

随着分子生物学的发展,基因工程小分子抗体以及纳米抗体由于其分子质量小、结构简单、异源性低、组织穿透能力强及易于大量生产等优点而越来越受到人们的关注,并且其与毒素、酶、细胞因子等生物活性物质融合可产生功能复合化抗体——抗体融合蛋白,在肿瘤的诊断和治疗中具有广阔的应用前景.本研究主要就小分子抗体、功能复合化抗体以及纳米抗体近几年的发展与应用进行综述.

With the development of molecular biology, gene-engineering small-molecular antibodies and nanobodies have become more and more important for their properties of small molecular weight, sim- ple structure, low immunogenicity, rapid penetration and economical produce and so on. These antibod- ies, which can be linked or fused to a vast range of molecules such as toxins, enzymes, cytokines, etc, have a great future in tumors diagnose and therapy. This review gives an overview on the development of antibodies of small-molecular and composite function and nanobodies in recent years.