米索前列醇预防产后大出血的临床观察

Clinical Observation of Misoprostol to Prevent Postpartum Hemorrhage

目的：观察米索前列醇预防产后大出血临床效果及安全性.方法：选取本院2011年3月～2012年3月收治的正常分娩产妇160例,随机分为两组,对照组80例给予缩宫素,实验组80例舌下含服米索前列醇；统计比较两组产后出血率,产后30min、2h和24h的累积出血量,产后血红蛋白、血细胞比容下降值及药物的不良反应发生率.结果：观察组产妇产后出血率,产后30min、2h、24h的累积出血量,血红蛋白、血细胞比容下降值均明显低于对照组（P＜0.05或P＜0.01）.结论：米索前列醇预防产后大出血疗效佳,应用安全.

Objective： To observe the clinical effect and safety of misoprostol to prevent postpartum hemorrhage. Methods： Selecting 160 cases of normal childbirth maternal in our hospital from March 2011 to March 2012, randomly divided into two groups, 80 cases for control group is given oxytocin, 80 cases for experimental group is by sublingual misopmstol; Statistically compare postpartum hemorrhage, postpartum 30rain, 2h and 24h cumulative amount of bleeding, decreased value of postpartum hemoglobin and hematocrit, and the incidence of adverse drug reactions of two groups . Results： Postpartum hemorrhage, postpartum 30rain, 2h, 24h cumulative amount of bleeding, and decreased values of hematocrit and hemoglobin in observation group were significantly lower than the control group＇ s （P 〈 0. 05 or P 〈 0. 01 ） . Conclusions： Using Misoprostol to prevent postpartum hemorrhage has good curative effect and application security.