非天然氨基酸修饰蛋白质研究进展

On the Modification of Proteins by Unnatural Amino Acids

蛋白质修饰是改善其物理化学和生物学特性的一种重要方法,目前已成为生物技术、生物催化和生物医学领域的研究热点.非天然氨基酸在蛋白质修饰中表现突出.介绍了非天然氨基酸种类及修饰方法,概述了其应用领域,以期为扩大利用此方法者提供参考.

Protein modification is an important method for improving the physicochemieat and biological characteristics of protein, which has become a hotspot of bio-technology and bio-catalytic and biomedical field. The unnatural amino acids have an outstanding performance in the protein modification. This paper introduced the type of unnatural amino acid and modification methods, and summarized its application fields to provide references for espending the use of this method.