鼻塞式无创同步间歇指令通气治疗新生儿肺透明膜病的疗效探讨

Discussion on the Effect of Nasal Synchronized Intermittent Mandatory Ventilation(NSIMV) on Neonates with Pulmonary Hyaline Membrane Disease

目的探讨鼻塞式无创同步间歇指令通气(Nsimv下同)对新生儿肺透明膜病(HMD下同)的治疗效果及安全性。方法将57例HMD患儿随机分为Nsimv组及NCPAP组进行监护治疗,观察其疗效及并发症。结果 NSIMV组与CPAP组比较气管插管例数、机械通气时间、呼吸暂停发生率明显减少,差异有统计学意义(P﹤0.05),并发症两组比较差异无统计学意义(P>0.05)。结论 NSIMV较NCPAP具有更好的疗效且安全性好,值得推广使用。

Objective To evaluate the effect and safety of nasal synchronized intermittent mandatory ventilation（NSIMV hereafter） on neonatal hyaline membrane disease（HMD hereafter）. Methods 57 neonates with HMD were divided into NSIMV group and NCPAP group randomly. The NSIMV group was treated with NSIMV, and the NCPAP group was treated with nasal continuous positive airway pressure（NCPAP）. The efficacy and complications of the groups were observed. Results The number of cases of tracheal intubation and the incidence of apnea of the NSIMV group were significantly less than those of the CPAP group, the time of mechanical ventilation was obviously shorter than that of the CPAP group, the differences were statistically significant（P0.05）. The difference in the incidence of complications between the groups was not statistically significant（P0.05）. Conclusion NSIMV is safer and more effective than NCPAP, which is worthy of promotion.