复方α-酮酸联合血液灌流对维持性血液透析患者微炎症状态的影响

The Effect of Compound α-keto Acid Combined with Blood Perfusion on the State of Micro-inflammation of Patients with Maintenance Hemodialysis

目的探讨复方α-酮酸联合血液灌流对维持性血液透析患者微炎症状态的影响。方法将60例维持性血液透析患者随机分为单纯血液灌流组(灌流组)、复方α-酮酸联合血液灌流组(联合组)各30例,于治疗0个月(治疗前)、3个月分别测定血中高敏C反应蛋白(hs-CRP)、白细胞介素6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)的水平。结果两组患者血hs-CRP、IL-6、TNF-α于治疗3个月均较治疗前下降(P<0.01),且联合组较灌流组下降更明显(P<0.05)。结论复方α-酮酸联合血液灌流对改善维持性血液透析患者微炎症状态有一定临床意义。

Objective To investigate the effect of compound α-keto acid combined with blood perfusion on the state of micro-inflammation of patients with maintenance hemodialysis. Methods 60 patients with maintenance hemodialysis were divided into 2groups randomly, blood perfusion group（perfusion group） and compound α-keto acid combined with blood perfusion group（combined group） with 30 cases in each.The concentrations of serum hs-CRP, IL-6 and TNF-α of the two groups were examined at 0month（before the treatment） and after 3 months of treatment, respectively. Results After 3 months＇ treatment, the concentrations of serum hs-CRP, IL-6 and TNF-α of the two groups were much lower than those before treatment with statistically significant differences（P0.01）. And the combined group＇s concentrations of TNF-α, hs-CRP and IL-6 were lower than those of the perfusion group with statistically significant differences（P0.05）. Conclusion Compound α- keto acid combined with blood perfusion has certain clinical significance in the improvement of micro-inflammatory state of patients with maintenance hemodialysis.