口服轮状病毒活疫苗预防轮状病毒肠炎效果评价

Effect Evaluation of Oral Rotavirus Vaccine in Prevention of Rotavirus Enteritis

目的探讨口服轮状病毒活疫苗预防轮状病毒肠炎的临床效果。方法选取该院2010年12月—2011年12月预防接种的健康婴幼儿482例,根据用药分为两组,208例婴幼儿未服用轮状病毒活疫苗为对照组,274例婴幼儿口服轮状病毒活疫苗为观察组,随访1年,分析婴幼儿的轮状病毒肠炎情况、住院患儿的临床指征和不良反应情况。结果观察组婴幼儿的轮状病毒肠炎发生率(1.5%)、住院患儿的不良反应发生率(25.0%)均明显低于对照组(9.1%)、(78.9%),观察组住院患儿的住院时间(4.1±0.5)d、大便频率(5.3±1.7)次/d均明显小于对照组(6.8±1.2)d、(8.4±2.0)次/d,差异有统计学意义(P<0.05)。结论口服轮状病毒活疫苗可有效预防轮状病毒肠炎的发生,明显缩短患儿住院时间,临床效果显著。

Objective To investigate the clinical effect of oral rotavirus vaccine on the prevention of rotavirus enteritis. Methods482 healthy infants underwent vaccination in our hospital from December, 2010 to December, 2011 were selected and divided into two groups, observation group（208 infants） and control group（274 infants） according to the vaccine they took. The observation group took rotavirus vaccine orally while the control group did not. All the infants were followed up for 1 year. The incidence of rotavirus enteritis, clinical indications and adverse reactions of hospitalized infants of the groups were analyzed. Results The incidences of rotavirus enteritis and adverse reactions of hospitalized infants of the observation group were significantly lower than those of the control group（1.5% vs.9.1%; 25.0% vs. 78.9%）; the average stay was obviously shorter than that of the control group（4.1 卤0.5d vs.6.8卤1.2d）; stool frequency was significantly less than that of the control group（5.3卤1.7 times/d vs. 8.4卤2.0 times/d）; the differences were statistically significant（P0.05）. Conclusion Taking rotavirus vaccine orally can not only effectively prevent rotavirus enteritis, but also shorten the length of stay with significant clinical efficacy.