酸枣仁治疗抑郁症的研究与应用

Application and research of spine date seed in treatment of depression

旨在探讨酸枣仁在治疗抑郁症中的应用。通过文献分析,结合抑郁症发病机制,总结其配伍应用规律。酸枣仁在治疗抑郁症复方中有养血宁心安神志、敛气润肺利宣肃、补肝温胆和脏腑、运脾和胃调中焦等功效,随证配伍,解郁安神。其抗抑郁机制主要涉及脑内单胺类递质、炎症细胞因子及神经营养因子等的调节。对其配伍应用及作用机制的深入研究,将为临床治疗抑郁症提供科学依据。

To explore the application of spine date seed in treatment of depression. Through literature analysis, combining with the pathogeuesis of depression, this paper summarizes the its law of combination and application. Spine date seed has the functions of nourishing blood and calming the heart to tranquilize the mind, astringing Qi and moisturizing the lung to promote its dispersing and descending tonifyiug the liver and warming the gallbladder to harmonize zang-fu viscera, and fortifying the spleen and harmonizing the stomach to regulate middle-jiao. Through the varied combination according to syndromes, it resolves depression and quiets the spirit. The antidepressant mechanism mainly involves the changes of monoamine neurotransmitters in the brain, inflammatory cytokines, neurotrophic factors, etc. In-depth study on its combination application and function mechanism will provide scientific basis for TCM clinical treatment of depression.