放线菌工业菌种选育、过程优化与放大研究进展

Industrial antibiotic-producing actinobacteria: from strain improvement to bioprocess optimization and scale-up

放线菌属由于能够产生一系列结构复杂的生物活性物质而受到广泛关注,这些活性代谢产物的大规模发酵生产在医药、农业等领域的应用中起着重要的作用。本文综述近年来放线菌次级代谢产物产业化研究的一些新进展,包括菌株的改造、生物过程优化和控制以及发酵放大技术,并对这些方法和技术进行讨论。

Actinobacteria are well known as they can produce a series of secondary metabo-lites with complex structures and various bioactivities. The industrial production of these sec- ondary metabolites plays a vital role in medical and agricultural fields. Recent advances in strain improvement, bioprocess optimization and control, and fermentation scale-up were re- viewed here. The holistic viewpoints and approaches applied in industrialized production of secondary metabolites by actinobacteria were discussed as well as the perspectives.