新方法新技术与新型抗生素发现

New methods, new technologies and discovery of novel antibiotics

日趋严峻的细菌耐药性问题给"抗生素传奇时代"带来了严重威胁,传统的抗菌药物开发手段已很难应对,因此急需新思路来寻找新型抗生素。近年来,一些新方法新技术如新型筛选模型的构建、基因组挖掘技术以及组合生物合成等给天然产物的筛选引发了革命性的变革,也为放线菌来源的新型抗生素的发现带来了新的希望。本文对这些新技术及其在新型抗生素研发中的应用进展进行阐述。

The growing bacteria drug resistance has seriously threatened the ＂antibiotic mira- cle＂, while traditional approaches for new antibiotics discovery could not combat this problem and novel solutions are urgently needed. Recently, new methods and technologies such as novel screening model establishment, genome mining and combinatorial biosynthesis have revolutionized the screening of natural products. Applying these technologies offers a unique opportunity to re-establish actinobecteria as a major source for drug discovery. These new ad- vances and technologies are described in this review.