非洛地平和硝苯地平及贝那普利治疗中青年舒张期高血压的疗效

Curative effects of felodipine, nifedipine and bnazepril on diastolic blood pressure of young and middle-aged hypertension patients

目的比较非洛地平、硝苯地平和贝那普利治疗中青年舒张期高血压的疗效。方法收集门诊中青年高血压患者90例,将患者分为非洛地平、硝苯地平和贝那普利组,每组30例。分别给予非洛地平(波依定)5mg、硝苯地平控释片(拜新同)30 mg或贝那普利(洛汀新)10 mg每日1次口服。干预(14±1)d后检测血压水平。记录不良反应。结果各组患者基线资料比较,差异无统计学意义。各组降压效果:收缩压,以硝苯地平组为佳(P<0.05);舒张压,非洛地平组显著优于硝苯地平组和贝那普利组(P<0.05),可以控制舒张压达到正常水平;心率,非洛地平影响较小,硝苯地平组和贝那普利组较快,后2者差异无统计学意义。不良反应各组发生率均低,差异无统计学意义。结论本研究发现非洛地平在降低舒张压方面存在优势。

Objective To compare the curative effects of felodipine, nifedipine and benazepril on diastolic blood pressure of young and middle-aged hypertension patients. Methods A total of 90 of young and middle-aged patients with diastolic hypertension were divided into 3 groups： felodipine （Boyiding, 5 rag, q.d. ）, nifedipine controlled release tablet （Baixintong, 30 mg, q.d. ） and benazepril （Lotensin, 10 mg, q.d. ） groups （30 cases in each group）. After the intervention[ （14 ＋ 1 ） days], the blood pressure levels were checked. Results For the baseline data, there was no statistically significant difference among the 3 groups. The nifedipine group was the best of all groups in the control of systolic blood pressure （P 〈 0.05） ; the felodipine group was significantly better than the nifedipine and benazepril groups in the control of diastolic blood pressure （ P ~ 0.05 ）, and in the felodipine group, the diastolic blood pressure was controlled to the normal level. Felodipine affected the heart rate rather low, but nifedipine and benazepril increased the heart rate, and there was no significant difference between the latter. The incidences of adverse reactions were very low in each group. Conclusions FelodiMne has an advantage in reducin~ the diastolic blood uressure.