188例慢性乙型肝炎病例的中医体质分布及其与HBV-DNA水平的相关性研究

Study on relativity between constitution distribution and HBV-DNA level in chronic hepatitis B:report of 188 cases

目的调查慢性乙型肝炎患者中医体质的分布规律,为临床治疗和预防提供依据。方法根据中华中医药学会"中医体质分类判定标准",对188例慢性乙型肝炎患者的中医体质进行调查,并分析其与HBV-DNA水平的相关性。结果本组患者中,气虚质占比最高(30.85%),其次为湿热质(28.72%)、气郁质(22.34%)、阴虚质(8.51%)、阳虚质(6.38%)、瘀血质(2.12%)、痰湿质(1.06%);中医体质与HBV-DNA水平具有相关性(P<0.05)。结论慢性乙型肝炎病例的中医体质以气虚质、湿热质、气郁质为主,其中气虚质患者的HBV-DNA水平多高于5.0×107拷贝/ml,湿热质和气郁质患者HBV-DNA水平多在1.0×104拷贝/ml～1.0×107拷贝/ml。

Objective To investigate the constitution distribution of chronic hepatitis B patients in TCM, and to provide the basis for clinical treatmem and prevention. Methods According to the Association of Chinese Medicine TCM constitution classification criteria, constitution distribution of 188 patients were investigated, and its relationship with HBV-DNA level was analyzed. Results In this group, the proportion of Qi deficiency constitution was the hightest （30.85%） , damp-heat constitution （ 28.72% ） , qi depression constitution （22.34%） , yin deficiency constitution （ 8. 51% ） , yaug deficiency constitution （6.38%）, blood stasis constitution（2.12% ）, phlegm-damp constitution （ 1.06% ） ; thel~ was relativity between constitution distribution and HBV-DNA level （P 〈0.05）. Conclusion Most of the patients are Qi deficiency constitution, damp-heat constitution, qi depression constitution. The HBV-DNA level of Qi deficiency patients is higher than 5.0×10^7 copy/ml, and lhe HBV-DNA level of damp-heat or qi depression constitution is 1.0 ×10^4-1.0 ×10^7 eopy/ml.