肝得宁胶囊对实验性肝损伤作用研究

Study of GDN Capsular on Experimental Liver Injury in Mice

目的 :观察肝得宁胶囊对实验性肝损伤的保护作用。方法 :应用四氯化碳 ( CCl4)、D-半乳糖胺 ( D-Gala)化学性肝损伤动物模型 ,以肝功能和病理改变为判断指标 ,对肝得宁胶囊的保肝作用进行实验。结果 :肝功能检测结果表明 ,肝得宁胶囊 0 .1875 g· kg- 1 ,和 0 .3 75 g· kg- 1均显著降低 CCl4,D-Gala化学性肝损伤小鼠血中谷丙转氨酶 ( AL T)的含量 ,与阳性药联苯双酯相比 ,无显著性差异 ( P>0 .0 5 )。肝病理镜检证实 ,该药有减轻中毒小鼠肝细胞的变性、坏死作用。结论 :肝得宁胶囊对化学性肝损伤有明显的保护作用 ,其疗效与肝得宁丸剂结果相似 。

AIM: To study the effect of GDN capsular (GDNC) on experimental liver injury. Methods: In the CCl 4、D Gala induced liver injury animal models, the protective liver effect of GDNC were observed by the index change of liver function and liver pathological examination. Results:The examined results of liver function showed that in CCl 4 and D Gala intoxicating mice models, after treatment with GDNC (0.187 5 g·kg 1 , 0.375 g·kg 1 ,0.562 g·kg 1 )po, the serum ALT were significantly lower than that of control respectively, compared with LB, no significance could be seen (P>0.05). The pathological examination showed that GDN could alleviate the level of the degeneration and necrosis of hepatic cells in the intoxicating mice. Conclusion: GDNC could significantly protect liver from injury and the results were consistent with that of GDN pill, GDNC is a safe and potential Chinese traditional drug in curing hepatitis.