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生物基质中蛋白质多肽类化合物的LC-MS法定量测定 被引量：5

Quantitative Assay of Proteins and Peptides Compounds in Biological Matrices by LC-MS
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摘要 蛋白质多肽类化合物及其药代动力学研究是近年来的研究热点,液相色谱-质谱联用技术(LC-MS)因其自身优势,在蛋白质多肽类化合物的研究中的应用越来越广泛。本文简要综述了LC-MS在生物基质中蛋白质多肽类化合物的定量分析时所使用的仪器、应用范围及样品处理方法。 The research of proteins and peptides compounds along with their pharmacokinetics have been hotpots recently. Chromatography coupled to mass spectrometry （LC-MS） has opened up broad prospect for the research of proteins and peptides compounds due to their own advantages. This paper briefly reviewed the equipments, applications and sample pretreatments of LC-MS methods in the quantitative assay of proteins and peptides compounds in biological matrices.
作者 刘俊华 葛庆华
机构地区 中国医药工业研究总院药物制剂国家工程研究中心
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2013年第10期1054-1060,共7页 Chinese Journal of Pharmaceuticals
关键词 蛋白质 多肽 液相色谱 质谱 定量分析 生物基质 综述 proteins peptides LC-MS quantitative assay biological matrices review
分类号 O657.72 [理学—分析化学]
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参考文献31

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同被引文献86

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中国医药工业杂志
2013年 第10期

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