摘要
以聚乙二醇聚(乳酸乙醇酸)共聚物(mPEG-PLGA)为材料,采用溶剂挥发法与快速膜乳化法制备了尺寸均一的mPEG-PLGA多孔微球,用其吸附降钙素,考察了降钙素浓度、吸附时间、离子浓度、温度及pH值及微球性质对吸附的影响.结果表明,优化的吸附条件为:降钙素浓度1.0 mg/mL,pH 7.4,NaCl浓度0.2 mol/L,14℃下吸附8 h,该条件下,微球吸附量为48.9 mg/g;吸附量与微球比表面积正相关.
Relatively uniform size porous methoxy poly（ethylene glycol-L-lactic-co-glycolic acid） （mPEG-PLGA） microspheres were successfully prepared by premix membrane emulsification with solvent evaporate method. The effects of salcatonin concentration, salt concentration, pH value, adsorption temperature and time, and properties of microspheres on the adsorption capacity of salcatonin were investigated. The results showed that the adsorption capacity of porous microspheres reached 48.9 mg/g under the conditions of 1.0 mg/mL salcatonin concentration, pH value 7.4 of phosphate buffer, 0.2 mol/L NaCl concentration, 14 ℃ adsorption temperature and 8 h adsorption time. In addition, the adsorption capacity increased with the increase of specific surface area.
出处
《过程工程学报》
CAS
CSCD
北大核心
2013年第5期870-876,共7页
The Chinese Journal of Process Engineering
基金
国家自然科学基金资助项目(编号:51173187
20706053)
关键词
mPEG—PLGA
多孔微球
降钙素
吸附
比表面积
methoxy poly（ethylene glycol-L-lactic-co-glycolic acid）
porous microspheres
salcatonin
adsorption
specific surface area
