血栓调节素与系统性红斑狼疮疾病活动相关性研究

Correlative analysis of thrombomodulin and activity of SLE

目的 :检测系统性红斑狼疮和原发性血管炎患者血浆血栓素水平 ,探讨TM与SLE活动的相关性及作为血管炎标记的意义。方法 :采用双抗体夹心ELISA法测定21例SLE ,7例血管炎患者和19例正常人的血浆TM水平 ,结果用SPSS软件进行分析。结果 :与正常人相比 ,活动期SLE患者及血管炎患者血浆TM水平显著高于正常对照 ( p<0.01);静止期SLE患者血浆TM水平与正常对照组之间无显著性差异。结论 :sTM可作为血管炎性病变的特异性标记 ,其检测对SLE病情活动的判断有一定的作用和意义。

Objective To investigate the plasma thrombomodulin(TM) levels in patients with SLE or primary vasculitis and its roles in the progression of diseases. Methods: 21 SLE patients, 7 primary vasculitis patients and 19 normal controls were chosen and the sTM levels were detected by sandwich ELISA. Results:Compared to the normal controls, the plasma TM levels were significantly higher in patients with primary vesculitis or active SLE. There was no statistical difference between inactive SLE patients and normal controls. Conclusion: TM may be a specific marker for primary vesculitis and the measurement of plasma TM level is a useful indicator for monitoring disease activity in SLE patients.