阻塞性睡眠呼吸暂停综合征对脑卒中患者认知功能的影响研究

A study of the effects of obstructive sleep apnea syndrome( OSAS ) on cognitive function in patients with cerebral infarction

目的探讨阻塞性睡眠呼吸暂停综合征((Obstructive sleep apnea syndrome,OSAS))对脑卒中患者认知功能的影响和认知损害特点。方法纳入急性脑梗死患者86例,根据多导睡眠监测仪(polysomnography,PSG)监测分为OSAS组21例,未合并OSAS组作为对照组65例,进行蒙特利尔认知评估量表北京版(The Montreal Cognitive Assessment,MoCA)评估。结果 OSAS组男性、合并高血压病和高脂血症的比例较对照组高(P<0.05);2组MoCA总分比较差异明显(P<0.05);2组在视空间与执行、命名能力、注意力、语言能力、抽象能力、延迟记忆能力、定向力7个认知域的评分差异均明显(P<0.05)。结论 OSAS可以加重脑卒中患者的认知功能障碍。

Objective To analyze the effects of obstructive sleep apnea syndrome （OSAS） on cognitive function in patients with cerebral infarction and to explore characteristics of cognitive impairment. Methods 86 patients with cerebral infarction were enrolled. According to the results of polysomnography, patients were divided into two groups： cerebral infarction with OSAS as study group and cerebral infarction without OSAS as control group. The Montreal Cognitive Assessment scale was used to assess cognitive functiorL Results Male patients with hypertension and hyperlipidemia were more common in OSAS group （P〈0. 05）. The difference of MoCA scores between OSAS and control group was statistically significant （P〈0. 05）. There was signifi- cant difference between the two groups in seven cognitive domains which were the visual space and execution, depending on-named ability, attention, language ability, abstract ability, delayed memory ability and directional power ability （P〈0. 05）. Conclusions OSAS exacerbates cognitive impairment of patients with cerebral infarction.