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帕金森病并发抑郁的研究进展 被引量:12

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摘要 帕金森病(Parkinson’s disease PD)是一种以静止性震颤、运动迟缓、肌强直和姿势步态异常等运动功能障碍为主要表现的神经系统变性疾病。除了运动功能障碍,大多数帕金森病患者都容易合并抑郁、情感淡漠、焦虑、认知功能障碍等非运动症状。抑郁症状可出现在帕金森病早期,甚至先于运动障碍出现,并伴随整个病程。目前无论是患者还是临床医生对帕金森病合并抑郁(DPD)的重视程度都不足,漏诊率很高。本研究将从帕金森病并发抑郁的流行病学、发病机制、临床表现、评价工具以及药物治疗等方面进行综述。
出处 《卒中与神经疾病》 2013年第5期316-318,共3页 Stroke and Nervous Diseases
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  • 1Reijnders JS, Ehrt U, Weber WE, et al. A systematic review of prevalence studies of depression in Parkinson's disease. Mov Dis- ord, 2008, 23(2):183 - 189.
  • 2Oliver Riedel, Jens Klotsche, Annika Spottke, et al. Frequency of dementia, depression, and other neuropsychiatric symptoms in 1449 outpatients with parkinson's disease. J Neurol, 2010, 257 (7):1073 - 1082.
  • 3Zgaljardic DJ, Foldi NS, Borod JC. Cognitive and behavioral dysfunction in Parkinsorrs disease neurochemieal and clinicopath- ological contributions. J Neural Transm, 2004, l 11 ( 10-11 ) : 1287-1301.
  • 4Strecker K, Wegner F, Hesse S, et al. Preserved serotonin transporter binding in de novo Parkinson's disease: negative cor- relation with the dopamine transporter. J Neurol, 2011,258(1 ) : 19-26.
  • 5Meyer PM, Strecker K, Kendziorra K, et al. Reduced alpha4beta2 * -nicotinic acetylcholine receptor binding and its re- lationship to mild cognitive and depressive symptoms in Parkin- son disease. Arch Gen Psychiatry, 2009,66(8) :866-877.
  • 6Carbon M, Ma Y, Barnes A, et al. Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation inParkinsonism. Neurolmage, 2004, 21 (4) : 1384 -1390.
  • 7Weintraub D, Newberg AB, Cary MS, et al. Striatal dopamine transporter imaging correlates with anxiety and depression symp- toms in Parkinson's disease. J Nucl Med, 2005,46 (2): 227-232.
  • 8Kostic VS,Agosta F, Petrovic I, et al. Regional patterns of brain tissue loss associated with depression in Parkinson disease. AJNR Am J Neuroradiol, 2{110,31 (10) : 186-1866.
  • 9李飞,谷德祥,李燕君,陈辉洲.帕金森病患者抑郁与脑功能相关研究[J].神经疾病与精神卫生,2002,2(5):280-282. 被引量:4
  • 10Chaudhuri KR, Healy DG, Schapira A. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neu- rol, 2006, 5(3) :235-245.

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