自噬与心肌缺血再灌注损伤

Autophagy and myocardial ischemia/reperfusion injury

自噬是将细胞内受损、变性或衰老的蛋白质以及细胞器运输到溶酶体进行消化降解的过程。大量研究证实自噬与心肌缺血再灌注损伤关系密切,现就自噬现象及自噬在心肌缺血再灌注过程中的诱发、作用性质及调节机制作一综述。

Summary Autophagy is a highly conserved catabolic process whereby a bulk of damaged, modified or aging proteins in the cytosol and organelles are transported to lysosomes for degradation. Research shows that autophagy is related to myocardial ischemia/reperfusion injury and plays a crucial role in this pathophysiological condition. This review will focus on the occurrence and development of autophagy and its role in myocardial ischemia/reperfu- sion injury. In addition, we will discuss the precipitating factor and the underlying signal mechanism of autophagy in rayocardial ischemia/reperfusion injury.