摘要
目的:分析血浆HDL-C亚型HDL2-C、HDL3-C水平与冠心病的关系,并观察冠心病患者HDL2/3-C水平变化对HDL-C的影响。方法:选择正常组135例和冠心病组318例,后者包括稳定型心绞痛58例、不稳定型心绞痛186例及急性心肌梗死74例,检测两组患者的血浆HDL-C及其亚型HDL2-C、HDL3-C水平,分析HDL-C亚型与冠心病的关系及其与HDL-C的相关性。结果:冠心病组HDL-C与HDL2-C水平均显著性低于对照组(均P<0.05),而两组HDL3-C水平差异无统计学意义;相关性分析显示,冠心病患者HDL2-C、HDL3-C与HDL-C均具有明显相关性,但HDL2-C(r=0.915,P<0.001)与HDL-C的相关性高于HDL3-C(r=0.356,P<0.001)与HDL-C的相关性。结论:冠心病患者HDL-C与HDL2-C水平显著降低,提示HDL-C与HDL2-C可能对冠心病具有保护作用,而低HDL-C水平主要与HDL2-C的降低有关。
Objective： To investigate the changes and clinical significances of HDL-C subclasses （HDL2--C, HDL3-C） in patients with coronary heart disease （CHD） and the effect of HDL2/3-C on HDL-C. Methods： HDL- C, HDL2-C and HDL3-C levels were detected in 135 controls with normal coronary artery （control group） and 318 CHD patients （CHD group）. CHD group included patients with stable angina pectoris （n= 58）, unstable angina pectoris （n= 186） and acute myocardial infarction （n= 74）. Relationship between HDL-C subclasses and CHD as well as HDL-C were analysed. Result： Levels of HDL-C and HDL2 C in CHD group were significantly lower than those in control group （both P〈0.05）. Correlation analysis showed that HDL2 C （r=0. 915, P〈0. 001） and HDL3-C （r=0. 356, P%0. 001） were significantly associated with HDL-C in CHD group, especially HDL2-C. Conclusion：Lower levels of HDL-C and HDL2-C are significantly associated with CHD, which indicates that HDL- C and HDL2-C may be protective factors in CHD. Lower level of HDL-C is mainly associated with decreased HDL2-C content in CHD patients.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2013年第10期756-758,共3页
Journal of Clinical Cardiology
基金
安徽省科技攻关项目(No:09010302083)
安徽省卫生厅医学科研重点项目(No:2010B005)
关键词
冠心病
高密度脂蛋白亚型
相关性
coronary heart disease
high density lipoprotein subclasses
correlation analysis
