骨髓增殖性肿瘤患者血栓栓塞的相关因素

Related Factors of Thrombosis in Patients with Myeloproliferative Neoplasms

目的研究BCR/ABL阴性骨髓增殖性肿瘤(myeloproliterative neoplasms,MPN)患者血栓栓塞的相关危险因素,用以指导临床。方法 104例MPN患者采用等位基因特异性PCR(AS-PCR)方法检测JAK2V617F突变情况,回顾性分析104例MPN患者临床特征、实验室检查及血栓栓塞事件发生情况等资料。先后行单因素分析和多因素分析。结果 104例MPN患者中71例(68.3%)存在JAK2V617F突变,45例有血栓栓塞(43.3%)。单因素分析表明,年龄、高血压病史、病种、JAK2V617F、白细胞计数(WBC)与血栓栓塞具有相关性(P<0.05);多因素分析表明,年龄(≥60岁)、JAK2V617F突变、白细胞计数升高是血栓栓塞的独立危险因素(P<0.05)。结论高龄、JAK2V617F突变阳性或白细胞计数增高的MPN患者血栓栓塞风险可能较高。

Objective To investigate the related risk factors of thrombosis in patients with BCR/ABL negative myeloproliferative neoplasms（MPN） for clinic. Methods The JAK2V617F mutation of 104 patients with MPN was detected by allele-specific polymerase chain reaction （AS-PCR） method. Clinical features, laboratory examinations and thrombosis studied. Univariate analysis was applied on the applied based on the univariate analysis. Results events of 104 patients with MPN were retrospectively pathologic information and multivariate analysis was Seventy-one cases of JAK2V617F mutation（68.3%） and 45 cases of thrombosis （43.3%） were identified in 104 patients with MPN. Univariate analysis revealed that age, hypertension, diagnosis, JAK2V617F and WBC were correlated with thrombosis （P〈0.05）. Multivariate analysis revealed that advanced age （ 〉~60 years ） , JAK2V617F mutation and increased WBC count were independent risk factors of thrombosis （P〈0.05）. Conclusion The thrombosis risk for MPN patients with advanced age, JAK2V617F mutation or increased WBC count may suffer high risk of thrombosis.