绝经后早期乳腺癌患者术后一年内发生骨密度减低的相关因素分析

Analysis on Related Factors of Bone Mineral Density Reduction in Postmenopausal Women with Early Breast Cancer One Year after Surgery

目的探讨影响绝经后早期乳腺癌患者术后一年内发生骨密度减低的相关因素。方法对242例绝经后早期乳腺癌患者临床资料进行回顾性分析,并对骨密度减低的相关因素进行单因素及多因素Logistic回归分析。结果对影响骨密度减少的10项指标进行单因素分析,显示年龄、BMI、绝经年限、AI内分泌治疗、雌二醇水平与骨密度减低显著相关(P<0.05);多因素Logistic回归分析显示绝经年限长、AI内分泌治疗、雌二醇低水平是骨密度减低的主要影响因素(P<0.05)。结论绝经后乳腺癌患者骨密度减低的主要影响因素是绝经年限长、AI内分泌治疗、雌二醇低水平,对于合并这些危险因素的乳腺癌患者,在临床工作中要足够重视并进行预防性和针对性治疗。

Objective To identify the related factors of bone mineral density reduction in postmenopausal women with early breast cancer 1 year after surgery.Methods The clinical data of 242 patients with early breast cancer of postmenopausal women in our hospital were collected and analyzed. Univariate and multivariate logistic regression model was used for analysis of related factors of bone mineral density reduction in postmenopausal women with breast cancer.Results Univariate logistic analysis on ten potential risk factors showed that age, BMI, Oral AI endocrine therapy, postmenopausal time and level of estradiol were significant variables affecting bone mineral density reduction（P 〈 0.05）. Multivariate logistic analysis showed that Oral AI endocrine therapy, long postmenopausal time and low level of estradiol were major risk factors（ P 〈 0.05）.Conclusion Oral AI endocrine therapy, long postmenopausal time, low level of estradiol are major risk factors of bone mineral density reduction of postmenopausal women with early breast cancer. We should pay great attention to the patients with these risk factors and carry out appropriate treatment to decrease bone loss incidence.