摘要
目的:评估壮医药线点灸联合柳氮磺吡啶(SASP)治疗轻、中度溃疡性结肠炎(UC)的疗效及安全性。方法:将符合纳入标准的46名UC患者按随机数字表法随机分为点灸组和对照组,每组23例。点灸组口服SASP,每次1g,3次/d,连续服用6周;同时施药线点灸,选用的穴位为天枢、气海、关元、大肠俞,每日灸1次,10次为1个疗程,疗程之间间隔2d,共计2个疗程。治疗结束时评估和比较两组的疗效、活动指数、镜下黏膜积分及不良反应发生情况。结果:点灸组的总有效率(95.65%,22/23)高于对照组(73.91%,17/23),P<0.05;两组的缓解率分别为39.13%(9/23)、26.09%(6/23),差异无统计学意义(P>0.05);治疗后,点灸组患者活动指数低于对照组(P<0.05);点灸组患者镜下黏膜积分低于对照组(P<0.05);在不良反应发生率方面,点灸组(4.35%,1/23)低于对照组(26.09%,6/23),P<0.05。结论:壮医药线点灸联合SASP是治疗UC的一种较为安全有效、操作简便的方法,具有疗效高、不良反应率低的优势。
Objective To observe the clinical effect and safety of Sulfasalazine (SASP) combined with ZHUANG medi cine mediated thread moxibustion (ZMMTM) for patients with mild and moderate ulcerative colitis (UO). Methods A total of 46 UG patients were randomly and equally divided into moxibustion group (SASP combined with ZMMTM) and SASP medication group. Patients of both groups were treated by oral administration of SASP (1 g, tid) for six weeks. For patients of the moxibus tion group, ZMMTM was applied to points Tianshu (ST 25), Qihai (OV 6), Guanyuan (OV 4), and Dachangshu (BL 25), once a day, for 20 times. The therapeutic effect was assessed according to Schroeder and colleagues' method (1987), scores of Baron' s endoscope scale (0- 9 scoring standards, 1964), 0- 3 scoring standards of activity indexes (including 4 items of diarrhea, hemorrhage, mucosal appearance and doctors evaluation), respectively. Results Of the two 32 UO patients in the medication and moxibustion groups, 6 and 9 had a complete remission in their symptoms, 6 and 7 experienced a remarkable improvement, 5 and 6 were effective, and 6 and 1 was invalid, with the effective rates being 73.91% and 95.65%, respectively. Following the treatment, both endoscopic score and activity index in the moxibustion group were significantly lower than those of the medication group (P〈0.05). Conclusion ZMMTM combined with medication is significantly superior to simple medication in relieving clinical symptoms of mild and moderate UG patients.
出处
《针刺研究》
CAS
CSCD
北大核心
2013年第5期399-402,共4页
Acupuncture Research
基金
广西自然科学基金项目(桂科政0472002-21)
关键词
溃疡性结肠炎壮医药线点灸柳氮磺吡啶
临床疗效黏膜损伤
活动指数
Ulcerative colitis
ZHUANG medicine mediated thread moxibustion
Sulfasalazine
Clinical effect
Mucosal lesion
Activity index