摘要
八聚体结合转录因子4(octamer-binding transcriptionfactor 4,Oct4)基因是POU转录因子家族中的一员,是维持干细胞多潜能性和自我更新的最重要转录因子之一.Oct4不仅在胚胎干细胞和生殖细胞及其肿瘤中有表达,且在多种体细胞恶性肿瘤中也均有表达现象,与恶性肿瘤患者的发生发展及临床预后存在密切的关系,对肿瘤的诊断及治疗有着深远的影响.本文就Oct4在消化系肿瘤中的作用及机制方面的研究给予综述.
Octamer-binding transcription factor 4 （Oct4）, a member of the POU transcription factor family, is one of the most important transcription factors for maintaining pluripotent and self-renewing state of stem cells. Oct4 is expressed not only in embryonic stem cells, germ cells and germ cell tumors but also in a variety of somatic cells of malignant tumors. The expression of Oct4 is closely related to the development and progno- sis of malignant tumors. Therefore, detection of Oct4 expression has great significance in the diagnosis and treatment of tumors. This article provides a brief review of the role of Oct4 in gas- trointestinal tumors.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第28期2969-2974,共6页
World Chinese Journal of Digestology
基金
贵州省科学技术基金资助项目
No.黔科合J字[2012]2365
国家自然科学基金资助项目
No.81260369~~
