香菇C_(91-3)菌丝发酵蛋白对S_(180)小鼠细胞免疫功能和IFN-γ及TNF-α的作用

The action of lentinus edodes C_(91-3) mycelium's fermentative protein on immune system of the mice with S_(180) tumor

目的观察香菇C91-3菌丝发酵蛋白对荷瘤小鼠免疫系统的作用。方法昆明小鼠24只,S180瘤细胞荷瘤建立动物模型,随机平均分为3组:香菇C91-3菌丝发酵蛋白治疗组、环磷酰胺治疗组、生理盐水对照组。观察香菇C91-3菌丝发酵蛋白对荷瘤小鼠NK细胞活性、淋巴细胞转化率、IFN-γ和TNF-α等免疫指标的影响。结果香菇C91-3菌丝发酵蛋白能够显著提高治疗组小鼠的NK细胞活性、淋巴细胞转化率和血清中IFN-γ和TNF-α的含量。结论香菇C91-3菌丝发酵蛋白能够显著提高荷瘤小鼠免疫系统的活性。

Objective To observe the action of lentinus edodes C91-3 mycelium＇s fermentative protein （ LFP91-3） on immune systemof the mice with S180 tumor. Methods Inbred male and female Kunming mice were used to create animal mode. Twenty-four mice wererandomly divided into LFP91.3 group, cyclophosphamide group and normal sodium control group. Then NK cell activity, lymphocyte trans-formation rate, serum IFN-γ and TNF-α were observed in comparison with the control groups. Results NK cell activity, lymphocytetransformation rate, serum IFN-γ and TNF-α in the treatment group of lentinus edodes C91-3 mycelium’s fermentative protein were higherthan those in other groups. Conclusion Lentinus edodes C91-3 mycelium＇s fermentative protein can enhance the activity of immune systemof mice with tumor.