2型糖尿病慢性肾脏疾病患者血清胱抑素C改变及临床意义

The changes and clinical significances in serum cystatin C in chronic kidney disease patients with T2DM

目的探讨T2DM慢性肾脏疾病(CKD)患者血清胱抑素C(Cys-C)改变及临床意义。方法选取CKD患者83例、T2DM患者98例及健康对照(NC)者100名,比较各组血清Cys-C、β2微球蛋白(β2-MG)、BUN、血清肌酐(Scr)和血清尿酸(SUA)等临床指标。结果 CKD组血清Cys-C水平高于T2DM、NC组,差异有统计学意义(P<0.01),同时测定β2-MG可提高CKD的异常检出率。结论血清Cys-C水平可作为肾小球滤过率(GFR)的判断指标之一,血清Cys-C水平与β2-MG、Scr呈正相关,与CCr呈负相关。

Objective To discuss the changes and clinical significances in serum cystatin C（Cys-C） in chronic kidney disease （CKD）patients with T2DM. Methods 83 T2DM patients with CKD, 98 T2DM patients, and 100 normal controls were enrolIed in the observation. The serum Cys-C, 132 microglobulin（132-MG）, BUN, serum creatinine（Ser）, and serum uric acid（SUA） were determined for comparison. Results The serum Cys-C was higher in the CKD group than in T2DM and NC groups and the difference was statistically significant（P〈0.01）. At the same time the measurement of 132-MG could improve the detectable rate of CKD. Conclusion Serum Cys-C can be taken as one of indices in diagnosing glomerular filtration rate（GFR）. The level of serum Cys-C is positively related with 132-MG and Scr and negatively with Ccr.