2-芳基苯丙酸类药物在混合溶剂中的荧光光谱

Fluorescence Properties of Drugs of 2-Arylpropionic Acid Family in Cosolvent Mixtures

测定了298K时2-芳基丙酸类药物普拉洛芬、酮洛芬、卡洛芬、萘普生在二元混合溶剂中的荧光光谱,采用Jouyban-Acree模型拟合了荧光强度(FI)数据,平均偏差为1.9%,当采用Yalkowsky方程拟合时,平均偏差达到13.5%。首次采用Jouyban-Acree模型拟合最大荧光发射波长,平均误差为0.3nm,而采用Y alkow sky方程时,误差为0.9nm。结果表明Jouy ban-A cree模型能够很好预测混合水溶液中药物的荧光强度及荧光最大发射波长,当数据较少时,Y alkow sky方程也能预测混合溶剂中的最大发射波长。

Fluorescence spectra of pranoprofen, ketoprofen, carprofen, and naproxen of 2-arylpropionic acid （profen） family in binary solvent mixtures at 298K were measured. The fluorescence intensity （FI） data are analyzed with the Jouyban-Acree model,and the mean relative deviation （MRD） is 1.9% ,and it is 13.5% when fitting with the log-linear model of Yalkowsky. The mean fitting errors of the emission wavelength of maximum fluorescence intensity （,lm） are 0. 9nm with the log-linear model and 0. 3nm with the Jouyban-Acree model. The results indicate that the Jouyban-Acree model could accurately predict the fluorescence properties of drugs in water co-solvents,the log-linear model of Yalkowsky is suited for predicting λm when lack of Data.