血小板膜蛋白结构改变在高原肺心病肺动脉高压致病中的作用及机理研究

Effect and mechanism of structural change of platelet membrane protein on pulmonary hypertension with high altitude corpulmonale

目的 探讨血小板膜蛋白结构改变在高原肺心病肺动脉高压中致病作用及机理。方法 运用多克隆抗体 ,流式细胞计等技术对 5 8例高原肺心病患者进行血小板膜结合纤维蛋白原和血小板膜糖蛋白Ⅲa免疫荧光测定 ,并进行心脏超声检查。结果 患者血小板膜结合纤维蛋白原、血小板膜糖蛋白、肺动脉压力和肺动脉阻力较正常对照组明显升高 (P <0 0 1) ,结合纤维蛋白原和糖蛋白Ⅲa愈高 ,肺动脉压升高愈明显。结论 血小板膜蛋白结构改变是高原肺心病肺动脉压增高重要致病因素之一。

Objective To research the structural change of platelet membrane protein in patients with high altitude cor pulmonale (CP).Methods Platelet bound fibrinogen(Fg)and membrane glycoprotein(Gp)Ⅲa and cardiac function were measured by flow cytometry and cardiac Doppler echocardiograghy in 58 patients with CP in high altitude .Results The levels of platelet bound Fg,membrane GPⅢ a and pulmonary artery pressure(PAP) were higher than those in normal subjects (P<0 01).PAP increased with increasing platelet bound Fg and GPⅢa.Conclusions High Fg and GPⅢa might be a pathophysiologic basis of prlnmonary hypertension patients with CP.