89例系统性红斑狼疮患者免疫指标测定的分析

Analysis of immunlolgy reference in eighty-nine patients with systemic lupus erythematosus

目的 :分析免疫学指标对诊断系统性红斑狼疮患者及病情监测的意义。方法 :分别应用单向免疫扩散法、间接免疫荧光法、快速斑点免疫金渗滤法、免疫印迹技术、形态学方法。结果 :活动期IgG、IgA、IgM升高 ,C3、C4 下降ANA抗体、dsDNA抗体及ENA抗体阳性 ,淋巴细胞转化率下降 ;非活动期IgG、IgA、IgM、C3、C4 近似参考值 ,ANA抗体、dsDNA抗体滴度下降或转阴 ,ENA抗体及淋巴细胞转化率无明显变化。结论 :免疫学检查是诊断系统性红斑狼疮重要的指标 ,ANA抗体dsDNA抗体 ,SM抗体是患者血清中的标志抗体。

Objective:To study immunology reference in patients with systemic lupus erythematous (SLE) and investigate its relationship with diagnosis and detection.Methods:IgG、IgA、IgM、C 3、C 4 was detected by single immunodiffasion,ANA was detected by fastly dot immanogold filtration assay,ENA antibody was used by immunoblotting teehnigue,lymphocyte transformation test was used by fornology technighe.Results:IgG、IgA、IgM raise in affecting in patients with SLE,C 3、C 4 going down,ANA antibody、ds-DNA antibody and ENA antibody is positive and lymphocyte transformation ratio goes doun.IgG、IgA、IgM、C 3、C 4、go to reference in non-affecting in patients with SLE,ANA-antibody ds-DNA antibody longitudinal go down or go negative,ENA antibody and lymphocyte.transformation ratio do not change.Conclusions:Reference.of SLE is diagnosed by immunology detection,ANA antibody、ds-DNA antibody and Sm antibody are the reference of antibody in serum in patients with SLE.