急性进展性脑梗死患者血浆纤维蛋白原及D-二聚体含量的测定及临床意义

Clinical value of plasma fibrinogen and D-dimer determination on patients with acute progressive cerebral infarction

目的 探讨急性进展性脑梗死患者血浆纤维蛋白原及D-二聚体的含量变化及临床价值.方法 回顾性分析96例急性脑梗死患者的临床资料,根据疾病进展与否将患者分为进展组40例和非进展组56例,并选择我院40例健康体检者纳入对照组.检测三组研究对象血浆纤维蛋白原及D-二聚体含量,动态比较两组脑梗死患者神经功能缺损评分的变化.结果 两组急性脑梗死患者的血浆纤维蛋白原及D-二聚体水平均显著高于对照组（P＜0.05）,D-二聚体阳性率均明显高于对照组（P＜0.05）,进展组患者上述指标均明显高于非进展组,差异有统计学意义（P＜0.05）；病程第7天及第21天进展组患者SSS评分均低于非进展组,差异均有统计学意义（P＜0.05）.结论 急性进展性脑梗死患者血浆纤维蛋白原及D-二聚体水平可出现明显升高,并与病情进展的呈密切相关.

Objective To investigate the clinical value of plasma fibrinogen and D-dimer determination patients with acute progressive cerebral infarction.Methods Ninety-six patients with acute progressive cerebral infarction （APCI） were divided into the progressive group （40 cases） and non-progressive group （56 cases） according to the disease progression or not,and 40 healthy subjects were included as the control group.The levels of plasma fibrinogen and D-dimer dynamic in the three groups were detected,and the cerebral infarction nerve function deficit score changes between the two groups were compared.Results The levels of fibrinogen and D-dimer were significantly higher in patients with APCI than those in control group （P ＜ 0.05）,and the D-dimer positive rate was significantly higher （P ＜ 0.05）,and those above indicators in progressive group was significantly higher than those in the non-progressive group,the differences were statistically significant （P ＜ 0.05） ; On the 7th day and 21st day,the SSS scores were lower than those in the non-progressive group,the differences were statistically significant（P ＜0.05）.Conclusions The plasma fibrinogen and D-dimer levels significantly increase in patients with APCI,and they are closely correlated with the progression of disease.