ABO血型不合新生儿的围生期状况分析

Analysis of perinatal condition of newborn with blood group incompatibitity

目的 对ABO血型不合新生儿的围生期状况进行分析,以探讨ABO血型不合溶血病发生的高危因素.方法 将876例母子ABO血型不合新生儿根据临床症状及血清特异性免疫抗体检查分为溶血组（126例）、非溶血黄疸组（130例）和健康组（620例）,对三组围生期状况进行回顾性分析.结果 三组在产妇年龄、人工流产史和分娩方式以及新生儿的性别、胎次、是否足月、出生体质量等方面比较差异均无统计学意义（P＞0.05）,而产前最后一次抗体效价、脐血总胆红素三组相比较差异有统计学意义（P＜0.05）.结论 ABO血型不合新生儿溶血病大多发病于生后（3.4±1.2）d,与孕期抗体效价增高和高脐血胆红素等高危因素有关.

Objective To investigate the risk factors for newborn hemolytic disease （HDN） by comparing the perinatal conditions of infants with ABO incompatible blood type.Methods From Jun.2011 to Jun.2012 in the third affiliated hospital of Zhengzhou university,a total of 876 infants with ABO incompatible blood type were classified into 3 groups according to the clinical symptoms and specific immune serum antibody test：hemolytic group （126 cases）,non-hemolytic group （130 cases） and healthy group （620 cases）.The perinatal conditions of the infants were reviewed retrospectively.Results There were no significant differences in maternal age,the history of induced abortion,the delivery mode,the gender,the times of pregnancies,the percentage of full-term infants,the birth weight among the three groups （P ＞ 0.05）.While the level of the serum antibody titers of IgG of antiA （B） before delivery and the cord bilirubin in HDN infants were higher than those in the other two groups,and there were significant differences among the three groups （P ＜ 0.05）.Conclusions The severity of HDN is related to the level of the serum antibody titers of IgG of antiA （B） before delivery and the cord bilirubin in infants.