高压氧联合推拿疗法及西酞普兰治疗脑卒中后抑郁的疗效

Curative effect of hyperbaric oxygen with massage and Citalopram to treat post-stroke depression

目的观察高压氧(hyperbaric oxygen,HBO)联合西酞普兰及推拿疗法治疗脑卒中后抑郁症的疗效。方法选择100例脑卒中后抑郁患者,采用随机数字表法将其分为治疗组及对照组各50例。两组患者均给予常规康复训练及西酞普兰等常规药物治疗,治疗组则在此基础上辅以推拿疗法及高压氧治疗。并于治疗前后行汉密尔顿抑郁量表(HAMD)、美国国立卫生研究院卒中量表(NIHSS)及改良Barthel Index(MBI)对两组患者抑郁程度、神经功能缺损及生活质量进行评定。结果治疗前两组患者HAMD、NIHSS及MBI评分组间比较差异无统计学意义(P均>0.05),经4周治疗后,发现两组患者上述指标均较治疗前明显改善(P<0.01),且治疗组的改善幅度相对较显著,与对照组比较差异有统计学意义(P<0.05)。结论高压氧联合西酞普兰及推拿疗法有助于进一步改善脑卒中后抑郁症患者神经受损功能,减轻抑郁程度,提高生活质量。

Objective To observe the curative effect of hyperbaric oxygen（HBO）combined with Citalopram and massage therapy on post-stroke depression.Methods A total of 100 patients with post-stroke depression were divided into treatment group and control group with fifty cases in each group according to random number table method. Two groups of patients were given routine rehabilitation training and conventional drug treatment of Citalopram, while the treatment group were also given hyperbaric oxygen and massage be- sides the above.And before and after the treatment ,the depression degree, neurologic impairment, and life quality of the two groups were assessed by Hamilton Depression Scale（HAMD）, National Institutes of Health Stroke Scale （NIHSS）and Modified Barthel Index （MBI）.Results Before treatment, the differences of HAMD, NIHSS, and MBI evaluation between the two groups were not of statisti- cal significance （P 〉 0.05）.After 4 weeks of treatment, the above indexes of the two groups were obviously improved （P 〈 0.01 ）, the treatment group had better improvement, and the differences between the two groups were of statistical significance（P 〈 0.05）.Conclu- sion Hyperbaric oxygen with massage and Citalopram can further contribute to the improvement of neurologic impairment of post-stroke depression sufferers, thus to relieve the depression and improve their life quality.