腹腔镜胆囊切除术后患者肝功能及免疫功能的变化

Changes in the liver function and immune function following laparoscopic cholecystectomy

目的:观察腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)对患者肝功能及免疫功能的影响。方法:回顾分析2010年1月至2012年1月为胆囊结石患者行开腹胆囊切除术(open cholecystectomy,OC)(n=65)及LC(n=65)的临床资料,对比两组患者肝功能及免疫功能的变化。结果:两组患者术后血清ALT、AST、TBIL均较术前升高,术后第5天恢复至正常水平。术后第1天、第3天,OC组ALT、AST、TBIL水平明显低于LC组,差异有统计学意义(P<0.05);免疫学指标IgA、IgM、IgG两组患者手术前后均无明显改变,差异无统计学意义(P>0.05)。结论:LC可造成患者肝功能明显升高,但术后可迅速恢复,对免疫功能无影响。

Objective：To investigate the effects of laparoscopic cholecystectomy （LC） on hepatic function and immune func- tion. Methods ： Retrospective analysis was made on the clinical data of 65 patients who accepted open cholecystectomy （OC） and 65 patients who accepted LC. The changes of liver function and immune function of the two groups were compared. Results ： The serum lev- els of ALT, AST and TBIL were elevated after the operation, and returned to normal on the 5th postoperative day in both groups. The lev- el of the 3 parameters of the OC group were statistically lower than those of the LC group on the 1st and 3rd day,there were statistically significant differences between the two groups （P 〈 0.05 ） ; but change of the immune function of the two groups were not statistically significant （P 〉 0.05 ）. Conclusions： After LC, liver functions increase significantly, but recover quickly. And LC has no significant effects on immune function.