三七通舒胶囊对缺血性卒中阿司匹林抵抗患者血小板聚集率、TXB_2及IL-6水平的影响

Effects ofSanqi Tongshu Capsule on Serum Levels of TXB_2 and IL-6 and Platlet Activity of Aspirin Resistance Patients with Ischemic Stroke

目的:探讨三七通舒胶囊对缺血性卒中阿司匹林抵抗(AR)患者血小板聚集率、血血栓烷B2(TXB2)白介素-6(IL-6)水平的影响。方法:从缺血性脑卒中患者中筛选140例AR患者,随机分为对照组(n=42)、三七通舒组(n=50)、西洛他唑组(n=48)。分别在用药前及用药后1个月测定血小板聚集率、血TXB2和IL-6水平。结果:三七通舒组和西洛他唑组与对照组比较:血小板聚集率显著下降(P<0.05);血TXB2和IL-6水平显著降低(P<0.05)。上述指标在两组间差异无统计学意义(P>0.05)。结论:三七通舒胶囊和西洛他唑可显著减少缺血性卒中患者阿司匹林抵抗的发生,同时对脑梗死AR患者脑损伤具有保护作用。

Objective： To investigate the effects of Sanqi Tongshu capsule on serum levels of TXB2 and IL-6 and platelet activity of aspirin resistance patients with isehemic stroke. Methods ： One handred and forty cases of AR patients with isehemic stroke were investigated. They were randomly divided into three groups ： control group, Sanqi Tongshu capsule group and cilostazol group. The serum levels of TXB2 and IL-6 and platelet aggregation were detected one month before and after treatment. Results ： Compared with the control group, the level of platelet aggregation, TXB2 and IL-6 ofSanqi Tongshu capsule group and cilostazol group were decreased statistically （ P〈O.05 ）. Conclusion ： Sanqi Tongshu capsule and cilostazol can significantly reduce the occurrence of aspirin resistance. Also they have protective effects on AR patients with ischemic stroke.