丹红注射液对血管性痴呆大鼠治疗作用实验研究

Experiment Research ofDanhong Injection for Treating Vascular Dementia in Rats

目的:丹红注射液对血管性痴呆大鼠治疗作用及可能机制。方法:将SD大鼠随机分为3组,假手术组、血管性痴呆组(对照组)、血管性痴呆丹红治疗组,2-AO法永久性结扎大鼠双侧颈总动脉制作大鼠血管性痴呆模型,治疗30 d后进行Y型电迷宫检测,处死大鼠取脑,测定VEGF及微血管密度的表达。结果:治疗组大鼠较对照组大鼠学习记忆能力改善。结论:丹红注射液可通过提高血管性痴呆患者血管再生能力改善其认知障碍。

Objective：To study the effects and possible mechanism of Danhong Injection in vascular dementia rats. Methods ： Sprague Dawley rats were divided into sham-operated group, vascular dementia group （ control group ） and w_scular dementia of Danhong Injection treatment group （ treatment group ）. The model of vascular dementia were established by 2-AO. The learning and memory ability of the rats were evaluated 30 clays after treatment. The rats were killed separately 30 clays after operation. The brainsections were used for testing the number of vascular endothelial growth factor （ VEGF ） and correlations with microvessel density （ MVD ）. Resuhs ： Learning and memory ability of treatment group were more significantly improved than those of control group. Conclusion ： Danbong Injection can effectively improve the learning and memory ability, and improve the expression of VEGF in VD rats.