血清性激素水平对痤疮发病的影响及治疗

Influence of Levels of Sex Hormones on Acne and Its Treatment

痤疮,俗称青春痘、粉刺,好发于青春期,是好发于毛囊、皮脂腺的慢性炎症性皮肤病,其作为一种损容性疾病,虽不危及生命,但可严重影响患者的容貌,对患者的生理与心理造成创伤,从而影响患者的生活质量。现代医学认为痤疮的发病机制主要有性激素水平作用包括睾酮、雌二醇、硫酸脱氢表雄酮、性激素结合球蛋白等,雄激素受体,毛囊皮脂导管角化异常,皮脂腺功能亢进,皮脂分泌过剩,毛囊内微生物,炎症反应、免疫机制、遗传和心理因素等等。现将性激素水平对痤疮发病的影响及其针对性治疗总结如下。

Acne,or simple pimple in common,is a worldwide problematic disease which occurs at the age of puberty and often continues into adulthood. It is a chronic and somehow complicated disorder characterized by both inflammatory and non inflammatory lesions. Besides scarring, the effect and impact of acne to one＇s psychological and emotional could literally be very critical. Clinical research has proved that the pathogenesis of aene is related to the levels of the sex hormones including Testosterone, Estrogen, DHEAs, SHBG, AR, inflammatory mediators, abnormal follicular kerotosis, hyperfunction of sebaceous gland, excess sebum secretion, microorganisms, immune mechanism, genetics and psychological factors. Influence of the levels of sex hormones on the incidence of acne and its targeted treatments are summarized as follows.