抗栓再造丸治疗中风后遗症临床研究

Clinical Research on Effect ofKangshuan Zaizao Pill in Patients with Stroke Sequelae

目的:观察抗栓再造丸对中风后遗症患者的疗效及血液流变学指标的影响。方法:随机选取400例中风后遗症患者,治疗组300例给予抗栓再造丸,对照组100例给予华佗再造丸,观察两组的临床疗效及血液流变学指标的变化。结果:与治疗前相比较,治疗组300例患者中风病积分和中医症候积分显著降低,治疗组180例患者治疗后全血高切黏度、全血低切黏度、纤维蛋白原均较治疗前有显著下降(P<0.01),但与对照组相比均无显著性差异,临床试验过程中未见明显副作用。结论:临床观察过程中未发现抗栓再造丸有不良反应发生,说明该药是治疗中风后遗症安全有效的内服中药。

Objective： To observe the effect of Kangshuan Zaizao Pill on stroke sequelae and impact of blood rheology indicators. Methods ： We randomly selected 400 cases of stroke sequelae, 300 cases for Kangshuan Zaizao Pill, 100 cases for Huatuo Zaizao Pill, and the clinical effect and the blood rheology indicators after 8 weeks were observed. Results ： After treatment, the points of 300 cases were lower in the stroke disease and TCM syndrome, and high shear whole blood viscosity, low shear whole blood viscosity and fibrinogen were remarkably decreased （P〈0.01）. But, compared with the control group, there was no significant difference. And there was no significant clinical side effect during the test. Conclusions ： We have not found adverse events during the clinical observation of the process, and it indicates Kangshuan Zaizao Pill is safe and effective to treat stroke sequelae.